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Article

TP53 mutants and non-HPV16/18 genotypes are poor prognostic factors for concurrent chemoradiotherapy in locally advanced cervical cancer.

Scientific reports - 28 Sept 2021

Kuno Ikumi, Takayanagi Daisuke, Asami Yuka, Murakami Naoya, Matsuda Maiko, Shimada Yoko, Hirose Sou, Kato Mayumi Kobayashi, Komatsu Masaaki, Hamamoto Ryuji, Okuma Kae, Kohno Takashi, Itami Jun, Yoshida Hiroshi, Shiraishi Kouya, Kato Tomoyasu

Abstract excerpt

Targeted sequencing for somatic mutations across the hotspots of 50 cancer-related genes was performed using biopsy specimens to investigate whether clinicopathological factors and genomic alterations correlated with prognosis in locally advanced cervical cancer. Seventy patients diagnosed with International Federation of Obstetrics and Gynecology (FIGO) stage III to IVA cervical cancer underwent radiotherapy or...

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Identifiers

PMID: 34584128
DOI: 10.1038/s41598-021-98527-2
PMCID: PMC8478905

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