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Article

The landscape of somatic mutations in Indonesian cervical cancer is predominated by the PI3K pathway.

Gynecologic oncology - 1 Jan 2018

Spaans Vivian M, Nyoman Bayu Mahendra I, Purwoto Gatot, Trietsch Marjolijn D, Osse Michelle, Ter Haar Natalja, Peters Alexander A W, Fleuren Gert J, Jordanova Ekaterina S

Abstract excerpt

OBJECTIVE: To investigate the prevalence of somatic mutations in Indonesian cervical carcinoma patients in the context of histology and human papillomavirus (HPV) type. METHODS: In total 174 somatic hot-spot mutations in 13 genes were analyzed by mass spectrometry in 137 Indonesian cervical carcinomas. RESULTS: In 66/137 tumors (48%) 95 mutations were identified. PIK3CA was most frequently mutated (24%), followed...

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PMID: 29113722
DOI: 10.1016/j.ygyno.2017.10.009

Genes

CTNNB1
PTEN
NRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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