Article

TP53 Mutants and Non-HPV16/18 Genotypes are Poor Prognostic Factors for Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer

2021-06-03

Abstract excerpt

Targeted sequencing for somatic mutations across the hotspots of 50 cancer-related genes was performed using biopsy specimens to investigate whether clinicopathological factors and genomic alterations correlated with prognosis in locally advanced cervical cancer. Seventy patients diagnosed with International Federation of Obstetrics and Gynecology (FIGO) stage III to IVA cervical cancer underwent radiotherapy or c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cbea67b-05ea-5c55-bd0f-99802064dbba
DOI: 10.21203/rs.3.rs-566513/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TP53 Mutants and Non-HPV16/18 Genotypes are Poor Prognostic Factors for Concurrent Chemoradiotherapy in Locally Advanced Cervical CancerDOI 10.21203/rs.3.rs-566513/v1Read

TP53 mutants and non-HPV16/18 genotypes are poor prognostic factors for concurrent chemoradiotherapy in locally advanced cervical cancer.Semantic proximity Read

Precise Classification of Cervical Carcinomas Combined with Somatic Mutation Profiling Contributes to Predicting Disease Outcome.Semantic proximity Read

Characterization of the Genomic Landscape in Cervical Cancer by Next Generation SequencingSemantic proximity Read

Genetic profiles of cervical tumors by high-throughput sequencing for personalized medical care.Semantic proximity Read

Exploiting somatic alterations as therapeutic targets in advanced and metastatic cervical cancer.Semantic proximity Read

Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations.Semantic proximity Read

Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical CancerSemantic proximity Read

Comprehensive Genomic Characterization of 102 Cervical Adenocarcinoma Tumors.Semantic proximity Read

Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix.Semantic proximity Read

Genomic Profiling of Chinese Cervical Cancer Patients Reveals Prevalence of DNA Damage Repair Gene Alterations and Related Hypoxia FeatureSemantic proximity Read

PIK3CA mutation and CNV status and post-chemoradiotherapy survival in patients with cervical cancer.Semantic proximity Read

Clinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcomeSemantic proximity Read