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Article

Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer.

Biochimica et biophysica acta. Reviews on cancer - 1 Apr 2017

Gatenby Robert A, Brown Joel

Abstract excerpt

The origin and progression of cancer is widely viewed as "somatic evolution" driven by the accumulation of random genetic changes. This theoretical model, however, neglects fundamental conditions for evolution by natural selection, which include competition for survival and a local environmental context. Recent observations that the mutational burden in different cancers can vary by 2 orders of magnitude and that...

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Identifiers

PMID: 28341421
DOI: 10.1016/j.bbcan.2017.03.005
PMCID: PMC5441954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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