Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?

Abstract excerpt

A widely accepted paradigm in cancer research holds that the development of cancers is rate limited by the occurrence of oncogenic mutations. In particular, the exponential rise in the incidence of most cancers with age is thought to reflect the time required for cells to accumulate the multiple oncogenic mutations needed to confer the cancer phenotype. Here I will argue against the axiom that the occurrence of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Age Factors
• Share to Aging
• Share to Cell Transformation, Neoplastic