Article

A generalized theory of somatic evolution

2018-04-09

Abstract excerpt

The modern Multi-Stage Model of Carcinogenesis (MMC) was developed in the 1950s through the ‘70s and postulated carcinogenesis as a process of rounds of Darwinian selection favoring progressively more malignant cell phenotypes. Through this period, almost nothing was known about driver mutations in cancers. Also, stem cells and cellular tissue organization were poorly characterized. The general multi-stage process...

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Literature Corpus work: 7aac6c84-aa79-5805-9624-746094094744
DOI: 10.1101/298422

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