Article
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.
PLoS biology - 30 Sept 2008
Li Ji, Ebata Atsushi, Dong Yuqing, Rizki Gizem, Iwata Terri, Lee Siu Sylvia
Abstract excerpt
The transcription factor DAF-16/forkhead box O (FOXO) is a critical longevity determinant in diverse organisms, however the molecular basis of how its transcriptional activity is regulated remains largely unknown. We report that the Caenorhabditis elegans homolog of host cell factor 1 (HCF-1) represents a new longevity modulator and functions as a negative regulator of DAF-16. In C. elegans, hcf-1 inactivation...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Nucleus
- Epistasis, Genetic
- Forkhead Transcription Factors
- Gene Expression Regulation
- Herbicides
- Host Cell Factor C1
- Longevity
- Models, Genetic
- Multiprotein Complexes