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Article

Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.

PLoS biology - 30 Sept 2008

Li Ji, Ebata Atsushi, Dong Yuqing, Rizki Gizem, Iwata Terri, Lee Siu Sylvia

Abstract excerpt

The transcription factor DAF-16/forkhead box O (FOXO) is a critical longevity determinant in diverse organisms, however the molecular basis of how its transcriptional activity is regulated remains largely unknown. We report that the Caenorhabditis elegans homolog of host cell factor 1 (HCF-1) represents a new longevity modulator and functions as a negative regulator of DAF-16. In C. elegans, hcf-1 inactivation...

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Identifiers

PMID: 18828672
DOI: 10.1371/journal.pbio.0060233
PMCID: PMC2553839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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