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Article

Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging.

PLoS genetics - 1 Jun 2018

Aalto Antti P, Nicastro Ian A, Broughton James P, Chipman Laura B, Schreiner William P, Chen Jerry S, Pasquinelli Amy E

Abstract excerpt

Argonaute (AGO) proteins partner with microRNAs (miRNAs) to target specific genes for post-transcriptional regulation. During larval development in Caenorhabditis elegans, Argonaute-Like Gene 1 (ALG-1) is the primary mediator of the miRNA pathway, while the related ALG-2 protein is largely dispensable. Here we show that in adult C. elegans these AGOs are differentially expressed and, surprisingly, work in...

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PMID: 29927939
DOI: 10.1371/journal.pgen.1007379
PMCID: PMC6013023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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