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RAD51 Gene Family Structure and Function

14 Jul 2020

Abstract excerpt

Accurate DNA repair and replication are critical for genomic stability and cancer prevention. RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double-strand break repair, replication stress, and meiosis. RAD51 is an ATPase that forms a nucleoprotein filament on single-stranded DNA. RAD51 has the function of finding and invading homologous DNA sequences to enable accurate and...

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PMID: 32663049
DOI: 10.1146/annurev-genet-021920-092410

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