Development of a flow cytometric method to detect the presence of mutated nucleophosmin 1 in acute myeloid leukemia.

Abstract excerpt

OBJECTIVE/BACKGROUND: Nucleophosmin 1 (NPM1) plays multiple roles in cell growth and proliferation. Deletion/insertion mutations in exon 12 of NPM1 (NPM1-DIM), commonly found in patients with acute myeloid leukemia (AML), alter the C-terminal amino acids and disrupt the normal nucleocytoplasmic shuttling function of the protein, which in turn leads to disease pathogenesis. However, this altered function as a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antibodies
• Share to Flow Cytometry
• Share to Leukemia, Myeloid, Acute