Article
A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias.
Blood - 23 Sept 2010
Gruszka Alicja M, Lavorgna Serena, Consalvo Maria Irno, Ottone Tiziana, Martinelli Chiara, Cinquanta Mario, Ossolengo Giuseppe, Pruneri Giancarlo, Buccisano Francesco, Divona Mariadomenica, Cedrone Michele, Ammatuna Emanuele, Venditti Adriano, de Marco Ario, Lo-Coco Francesco, Pelicci Pier Giuseppe
Abstract excerpt
Mutations in the nucleophosmin 1 (NPM1) gene are the most frequent genetic aberrations of acute myeloid leukemia (AML) and define a clinically distinct subset of AML. A monoclonal antibody (T26) was raised against a 19-amino acid polypeptide containing the unique C-terminus of the type A NPM1 mutant protein. T26 recognized 10 of the 21 known NPM1 mutants, including the A, B, and D types, which cover approximately...
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