Article
Baseline immunophenotypic profile of bone marrow leukemia cells in acute myeloid leukemia with nucleophosmin-1 gene mutation: a EuroFlow study
4 Sept 2023
Abstract excerpt
Molecular techniques are the gold standard method for the diagnosis of AML with mutated nucleophosmin gene ( NPM1 mut ). However, their worldwide availability is limited and they provide limited insight into disease heterogeneity. Hence, surrogate markers of NPM1 mut are used for fast diagnostic screening of the disease [ 1 ], including, among others, immunohistochemical detection of cytoplasmic NPM1 (NPM1c) [ 2...
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