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Article

Flow cytometry in detection of Nucleophosmin 1 mutation in acute myeloid leukemia patients: A reproducible tertiary hospital experience.

International journal of laboratory hematology - 1 Feb 2021

El-Gamal Rasha Abd El-Rahman, Hashem Azza El-Sayed, Habashy Deena Mohamed, Abou Elwafa Menna Allah Zakareya, Boshnak Noha Hussein

Abstract excerpt

INTRODUCTION: Nucleophosmin 1 (NPM1) mutation is one of the most frequent gene mutations in adult acute myeloid leukemia (AML), being detected in 35% of all cases and in up to 60% of patients with normal karyotype AML. AML with mutated NPM1 has distinct pathology, immunophenotyping, and confirmed favorable prognostic significance. Hence, AML with mutated NPM1 is a separate entity in the revised 2016 World Health...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32856429
DOI: 10.1111/ijlh.13317

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