Article
Detection of nucleophosmin gene mutations in plasma from patients with acute myeloid leukemia: clinical significance and implications.
Cancer biomarkers : section A of Disease markers - 1 Jan 2009
Ma Wanlong, Kantarjian Hagop, Zhang Xi, Jilani Iman, Sheikholeslami Mohammad R, Donahue Amber C, Ravandi Farhad, Estey Elihu, O'Brien Susan, Keating Michael, Giles Francis J, Albitar Maher
Abstract excerpt
Roughly one-third of acute myeloid leukemia (AML) patients exhibit mutations in the nucleophosmin (NPM1) gene, and multiple studies have linked these mutations with a more favorable clinical outcome. We developed an assay for the detection of NPM1 mutations in peripheral blood plasma, and compared the results with clinical outcomes from a single institution. Analyzing plasma from previously untreated AML patients...
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