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Article

Nucleophosmin gene mutations in acute myeloid leukemia.

Archives of pathology & laboratory medicine - 1 Nov 2006

Chen Weina, Rassidakis Georgios Z, Medeiros L Jeffrey

Abstract excerpt

CONTEXT: Heterozygous mutation of the nucleophosmin gene (NPM1) has recently been described as one of the most frequent genetic lesions in acute myeloid leukemia (AML). OBJECTIVE: (1) To discuss the clinical, morphologic, immunophenotypic, and genetic features of AML with NPM1 gene mutations, along with various detection methods, (2) To explore the mechanisms by which NPM1 gene mutations contribute to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17076533
DOI: 10.5858/2006-130-1687-NGMIAM

Genes

NPM1
FLT3
MDM2

Provenance

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