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Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives.

Current opinion in oncology - 1 Nov 2009

Falini Brunangelo, Sportoletti Paolo, Martelli Maria Paola

Abstract excerpt

PURPOSE OF REVIEW: Nucleophosmin (NPM1) gene mutations, which cause aberrant cytoplasmic expression of nucleophosmin (NPMc+), are the most frequent genetic alteration in acute myeloid leukemia (AML), being found in about 30% cases. The present review summarizes recent advances in the biology, diagnosis, prognosis and therapy of NPM1-mutated AML. RECENT FINDINGS: Diagnostic criteria of NPM1-mutated AML are...

Topics

Acute Disease
Base Sequence
Genetic Predisposition to Disease
Humans
Leukemia, Myeloid
Molecular Sequence Data
Mutation
Nuclear Proteins
Nucleophosmin
Prognosis

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Identifiers

PMID: 19770764
DOI: 10.1097/CCO.0b013e3283313dfa

Genes

NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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