NPM1-Mutated Acute Myeloid Leukemia: Recent Developments and Open Questions.

Abstract excerpt

Somatic mutations in the nucleophosmin (NPM1) gene occur in approximately 30% of de novo acute myeloid leukemias (AMLs) and are relatively enriched in normal karyotype AMLs. Earlier World Health Organization (WHO) classification schema recognized NPM1-mutated AMLs as a unique subtype of AML, while the latest WHO and International Consensus Classification (ICC) now consider NPM1 mutations as AML-defining, albeit...

Topics

• Humans
• Alleles
• Leukemia, Myeloid, Acute
• Mutation
• Nuclear Proteins
• Nucleophosmin