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NPM1-Mutated Acute Myeloid Leukemia: Recent Developments and Open Questions.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2024

Patel Sanjay S

Abstract excerpt

Somatic mutations in the nucleophosmin (NPM1) gene occur in approximately 30% of de novo acute myeloid leukemias (AMLs) and are relatively enriched in normal karyotype AMLs. Earlier World Health Organization (WHO) classification schema recognized NPM1-mutated AMLs as a unique subtype of AML, while the latest WHO and International Consensus Classification (ICC) now consider NPM1 mutations as AML-defining, albeit...

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Identifiers

PMID: 36944324
DOI: 10.1159/000530253
PMCID: PMC10857804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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