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Article

Detection of cytoplasmic nucleophosmin expression by imaging flow cytometry.

Cytometry. Part A : the journal of the International Society for Analytical Cytology - 1 Oct 2012

Grimwade Lizz, Gudgin Emma, Bloxham David, Bottley Graham, Vassiliou George, Huntly Brian, Scott Mike A, Erber Wendy N

Abstract excerpt

Mutations within the nucleophosmin NPM1 gene occur in approximately one-third of cases of acute myeloid leukemia (AML). These mutations result in cytoplasmic accumulation of the mutant NPM protein. NPM1 mutations are currently detected by molecular methods. Using samples from 37 AML patients, we investigated whether imaging flow cytometry could be a viable alternative to this current technique. Bone...

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Identifiers

PMID: 22968966
DOI: 10.1002/cyto.a.22116

Genes

NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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