Article
Effect of Oophorectomy on Survival After Breast Cancer in BRCA1 and BRCA2 Mutation Carriers.
JAMA oncology - 1 Jun 2015
Metcalfe Kelly, Lynch Henry T, Foulkes William D, Tung Nadine, Kim-Sing Charmaine, Olopade Olufunmilayo I, Eisen Andrea, Rosen Barry, Snyder Carrie, Gershman Shelley, Sun Ping, Narod Steven A
Abstract excerpt
IMPORTANCE: Women who carry a germline mutation in either the BRCA1 or BRCA2 gene face a lifetime risk of breast cancer of up to 70%, and once they receive a diagnosis of breast cancer, they face high risks of both second primary breast and ovarian cancers. Preventive bilateral salpingo-oophorectomy is recommended to women with a BRCA mutation at age 35 years or thereafter to prevent breast and ovarian cancer,...
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