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Article

Prophylactic oophorectomy reduces breast cancer penetrance during prospective, long-term follow-up of BRCA1 mutation carriers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Dec 2005

Kramer Joan L, Velazquez Isela A, Chen Bingshu E, Rosenberg Philip S, Struewing Jeffery P, Greene Mark H

Abstract excerpt

PURPOSE: Breast cancer penetrance estimates in BRCA1 mutation carriers have varied from 40% to 85%; this heterogeneity has been attributed to variations in risk among different study populations. No study has taken oophorectomy status into account in estimating penetrance. Because prophylactic oophorectomy reduces breast cancer risk by approximately 50%, we hypothesized that population differences in oophorectomy...

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Source

Identifiers

PMID: 16314625
DOI: 10.1200/JCO.2005.02.9199

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prophylactic oophorectomy reduces breast cancer penetrance during prospective, long-term follow-up of BRCA1 mutation carriers.PMID 16314625Read ↗

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