Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study.

doi:10.1200/JCO.2004.00.7138

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Article

Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Oct 2005

Eisen Andrea, Lubinski Jan, Klijn Jan, Moller Pal, Lynch Henry T, Offit Kenneth, Weber Barbara, Rebbeck Tim, Neuhausen Susan L, Ghadirian Parviz, Foulkes William D, Gershoni-Baruch Ruth, Friedman Eitan, Rennert Gadi, Wagner Teresa, Isaacs Claudine, Kim-Sing Charmaine, Ainsworth Peter, Sun Ping, Narod Steven A

Abstract excerpt

PURPOSE: The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with age at oophorectomy, age at diagnosis, and time elapsed since surgery. PATIENTS AND METHODS: We analyzed 1,439 patients with breast cancer and 1,866 matched controls derived from a...

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PMID: 16234515
DOI: 10.1200/JCO.2004.00.7138

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BRCA1
BRCA2

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