Article
Bilateral Oophorectomy and the Risk of Breast Cancer in BRCA1 Mutation Carriers: A Reappraisal.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2022
Kotsopoulos Joanne, Lubinski Jan, Gronwald Jacek, Menkiszak Janusz, McCuaig Jeanna, Metcalfe Kelly, Foulkes William D, Neuhausen Susan L, Sun Sophie, Karlan Beth Y, Eisen Andrea, Tung Nadine, Olopade Olufunmilayo I, Couch Fergus J, Huzarski Tomasz, Senter Leigha, Bordeleau Louise, Singer Christian F, Eng Charis, Fruscio Robert, Pal Tuya, Sun Ping, Narod Steven A
Abstract excerpt
BACKGROUND: The lack of consensus on whether bilateral oophorectomy impacts risk of developing breast cancer among BRCA1 mutation carriers might be attributed to various biases, specifically, cancer-induced testing bias due to inclusion of prevalent cases. We conducted two complementary matched case-control analyses to evaluate the association of oophorectomy and BRCA1 breast cancer. METHODS: A research...
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