Article
Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation.
JAMA - 12 Jul 2006
Finch Amy, Beiner Mario, Lubinski Jan, Lynch Henry T, Moller Pal, Rosen Barry, Murphy Joan, Ghadirian Parviz, Friedman Eitan, Foulkes William D, Kim-Sing Charmaine, Wagner Teresa, Tung Nadine, Couch Fergus, Stoppa-Lyonnet Dominique, Ainsworth Peter, Daly Mary, Pasini Babara, Gershoni-Baruch Ruth, Eng Charis, Olopade Olufunmilayo I, McLennan Jane, Karlan Beth, Weitzel Jeffrey, Sun Ping, Narod Steven A
Abstract excerpt
CONTEXT: Women with BRCA1 or BRCA2 mutation are often advised to undergo preventive oophorectomy. The effectiveness of this intervention has not been prospectively evaluated in a large cohort. OBJECTIVES: To estimate the incidence of ovarian, fallopian tube, and primary peritoneal cancer in women who carry a deleterious mutation in BRCA1 or BRCA2. To estimate the reduction in risk of these cancers associated with...
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