Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.

doi:10.1158/1055-9965.EPI-12-0201

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Article

Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2012

Kotsopoulos Joanne, Lubinski Jan, Lynch Henry T, Kim-Sing Charmaine, Neuhausen Susan, Demsky Rochelle, Foulkes William D, Ghadirian Parviz, Tung Nadine, Ainsworth Peter, Senter Leigha, Karlan Beth, Eisen Andrea, Eng Charis, Weitzel Jeffrey, Gilchrist Dawna M, Blum Joanne L, Zakalik Dana, Singer Christian, Fallen Taya, Ginsburg Ophira, Huzarski Tomasz, Sun Ping, Narod Steven A

Abstract excerpt

BACKGROUND: To evaluate the effect of the cumulative number of ovulatory cycles and its contributing components on the risk of breast cancer among BRCA mutation carriers. METHODS: We conducted a matched case-control study on 2,854 pairs of women with a BRCA1 or BRCA2 mutation. Conditional logistic regression was used to estimate the association between the number of ovulatory cycles and various exposures and the...

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Identifiers

PMID: 22564871
DOI: 10.1158/1055-9965.EPI-12-0201
PMCID: PMC3593267

Genes

BRCA1
BRCA2
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Source receipt: pubmed, retrieved 6 Sept 2026.

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