Article
Effect of amino acid sequence variations at position 149 on the fusogenic activity of the subtype B avian metapneumovirus fusion protein.
Archives of virology - 1 Oct 2015
Yun Bingling, Gao Yanni, Liu Yongzhen, Guan Xiaolu, Wang Yongqiang, Qi Xiaole, Gao Honglei, Liu Changjun, Cui Hongyu, Zhang Yanping, Gao Yulong, Wang Xiaomei
Abstract excerpt
The entry of enveloped viruses into host cells requires the fusion of viral and cell membranes. These membrane fusion reactions are mediated by virus-encoded glycoproteins. In the case of avian metapneumovirus (aMPV), the fusion (F) protein alone can mediate virus entry and induce syncytium formation in vitro. To investigate the fusogenic activity of the aMPV F protein, we compared the fusogenic activities of...
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