Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Residues of the human metapneumovirus fusion (F) protein critical for its strain-related fusion phenotype: implications for the virus replication cycle.

Journal of virology - 1 Dec 2011

Mas Vicente, Herfst Sander, Osterhaus Albert D M E, Fouchier Ron A M, Melero José A

Abstract excerpt

The paramyxovirus F protein promotes fusion of the viral and cell membranes for virus entry, as well as cell-cell fusion for syncytium formation. Most paramyxovirus F proteins are triggered at neutral pH to initiate membrane fusion. Previous studies, however, demonstrated that human metapneumovirus (hMPV) F proteins are triggered at neutral or acidic pH in transfected cells, depending on the strain origin of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Giant Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histidine

Share to Membrane Fusion

Share to Metapneumovirus

Share to Paramyxoviridae Infections

Share to Vero Cells

Share to Viral Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21937649
DOI: 10.1128/JVI.05485-11
PMCID: PMC3209396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Residues of the human metapneumovirus fusion (F) protein critical for its strain-related fusion phenotype: implications for the virus replication cycle.PMID 21937649Read ↗

Low-pH-Induced Membrane Fusion Mediated by Human Metapneumovirus F Protein Is a Rare, Strain-Dependent PhenomenonSemantic proximity Read ↗

Localization of a region in the fusion protein of avian metapneumovirus that modulates cell-cell fusion.Semantic proximity Read ↗

Trypsin- and low pH-mediated fusogenicity of avian metapneumovirus fusion proteins is determined by residues at positions 100, 101 and 294.Semantic proximity Read ↗

Characterization of human metapneumovirus F protein-promoted membrane fusion: critical roles for proteolytic processing and low pH.Semantic proximity Read ↗

Mutations in the fusion protein heptad repeat domains of human metapneumovirus impact on the formation of syncytia.Semantic proximity Read ↗

Breaking In: Human Metapneumovirus Fusion and EntrySemantic proximity Read ↗

A conserved region in the F(2) subunit of paramyxovirus fusion proteins is involved in fusion regulation.Semantic proximity Read ↗

Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoproteinSemantic proximity Read ↗

The paramyxovirus fusion protein C-terminal region: mutagenesis indicates an indivisible protein unit.Semantic proximity Read ↗

Fusion protein of the paramyxovirus SV5: destabilizing and stabilizing mutants of fusion activation.Semantic proximity Read ↗

Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion.Semantic proximity Read ↗

Paramyxovirus Fusion and Entry: Multiple Paths to a Common EndSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.