Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low-pH-Induced Membrane Fusion Mediated by Human Metapneumovirus F Protein Is a Rare, Strain-Dependent Phenomenon

3 Jul 2008

Abstract excerpt

Membrane fusion promoted by human metapneumovirus (HMPV) fusion (F) protein was suggested to require low pH (R. M. Schowalter, S. E. Smith, and R. E. Dutch, J. Virol. 80:10931-10941, 2006). Using prototype F proteins representing the four HMPV genetic lineages, we detected low-pH-dependent fusion only with some lineage A proteins and not with lineage B proteins. A glycine at position 294 was found responsible for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Respiratory viral infections research
Share to Viral gastroenteritis research and epidemiology
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18596097
DOI: 10.1128/jvi.00472-08

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-pH-Induced Membrane Fusion Mediated by Human Metapneumovirus F Protein Is a Rare, Strain-Dependent PhenomenonPMID 18596097Read ↗

Residues of the human metapneumovirus fusion (F) protein critical for its strain-related fusion phenotype: implications for the virus replication cycle.Semantic proximity Read ↗

Trypsin- and low pH-mediated fusogenicity of avian metapneumovirus fusion proteins is determined by residues at positions 100, 101 and 294.Semantic proximity Read ↗

Localization of a region in the fusion protein of avian metapneumovirus that modulates cell-cell fusion.Semantic proximity Read ↗

Characterization of human metapneumovirus F protein-promoted membrane fusion: critical roles for proteolytic processing and low pH.Semantic proximity Read ↗

Human metapneumovirus G protein is highly conserved within but not between genetic lineages.Semantic proximity Read ↗

Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoproteinSemantic proximity Read ↗

Breaking In: Human Metapneumovirus Fusion and EntrySemantic proximity Read ↗

Mutations in the fusion protein heptad repeat domains of human metapneumovirus impact on the formation of syncytia.Semantic proximity Read ↗

Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years.Semantic proximity Read ↗

Limited inter- and intra-patient sequence diversity of the genetic lineage A human metapneumovirus fusion gene.Semantic proximity Read ↗

Effects of N-linked glycosylation of the fusion protein on replication of human metapneumovirus in vitro and in mouse lungsSemantic proximity Read ↗

Structure, immunogenicity, and conformation-dependent receptor binding of the post-fusion human metapneumovirus F proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.