Effects of N-linked glycosylation of the fusion protein on replication of human metapneumovirus in vitro and in mouse lungs

Abstract excerpt

The fusion (F) protein is an important membrane glycoprotein necessary for cellular entry and replication of human metapneumovirus (hMPV). Selective prevention of N-linked glycosylation may compromise the catalytic and fusion functions of the F protein. By using site-directed mutagenesis and reverse genetics, recombinant mutant viruses lacking one or two N-linked glycosylation sites in the F protein were...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Parvovirus B19 Infection Studies
• Share to Respiratory viral infections research
• Share to Viral gastroenteritis research and epidemiology