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Article

The paramyxovirus fusion protein C-terminal region: mutagenesis indicates an indivisible protein unit.

Journal of virology - 1 Mar 2012

Zokarkar Aarohi, Lamb Robert A

Abstract excerpt

Paramyxoviruses enter host cells by fusing the viral envelope with a host cell membrane. Fusion is mediated by the viral fusion (F) protein, and it undergoes large irreversible conformational changes to cause membrane merger. The C terminus of PIV5 F contains a membrane-proximal 7-residue external region (MPER), followed by the transmembrane (TM) domain and a 20-residue cytoplasmic tail. To study the sequence...

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Identifiers

PMID: 22171273
DOI: 10.1128/JVI.06546-11
PMCID: PMC3302293

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