Article
Mutations in the fusion protein heptad repeat domains of human metapneumovirus impact on the formation of syncytia.
The Journal of general virology - 1 Jun 2017
Dubois Julia, Cavanagh Marie-Hélène, Terrier Olivier, Hamelin Marie-Ève, Lina Bruno, Shi Rong, Rosa-Calatrava Manuel, Boivin Guy
Abstract excerpt
Human metapneumovirus (HMPV) is an important cause of respiratory tract infections. The mechanism by which its fusion (F) protein is responsible for variable cytopathic effects in vitro remains unknown. We aligned the F sequences of the poorly fusogenic B2/CAN98-75 strain and the hyperfusogenic A1/C-85473 strain and identified divergent residues located in the two functional heptad repeats domains (HRA and HRB)....
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