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Article

Trypsin- and low pH-mediated fusogenicity of avian metapneumovirus fusion proteins is determined by residues at positions 100, 101 and 294.

Scientific reports - 26 Oct 2015

Yun Bingling, Guan Xiaolu, Liu Yongzhen, Gao Yanni, Wang Yongqiang, Qi Xiaole, Cui Hongyu, Liu Changjun, Zhang Yanping, Gao Li, Li Kai, Gao Honglei, Gao Yulong, Wang Xiaomei

Abstract excerpt

Avian metapneumovirus (aMPV) and human metapneumovirus (hMPV) are members of the genus Metapneumovirus in the subfamily Pneumovirinae. Metapneumovirus fusion (F) protein mediates the fusion of host cells with the virus membrane for infection. Trypsin- and/or low pH-induced membrane fusion is a strain-dependent phenomenon for hMPV. Here, we demonstrated that three subtypes of aMPV (aMPV/A, aMPV/B, and aMPV/C) F...

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PMID: 26498473
DOI: 10.1038/srep15584
PMCID: PMC4620442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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