Article
Mutation of lysine 396 of the fusion protein reduces its binding affinity with integrin αVβ1 and leads to attenuation of avian metapneumovirus subtype B.
mBio - 13 May 2026
Meng Lingzhai, Chen Yuntong, Yu Mengmeng, Liu Yongzhen, Wang Suyan, Xue Xiaoxiao, Fan Wenrui, Wang Ying, Zhang Tao, Guo Peidong, Guo Ru, Hu Mingxue, Qi Xiaole, Zhang Yanping, Duan Yulu, Cui Hongyu, Gao Yulong
Abstract excerpt
Avian metapneumovirus subtype B (aMPV/B) infections significantly affect the global poultry industry. However, the virulence determinants and attenuation mechanism remain unknown. Here, a series of chimeric and mutant viruses was constructed, and their pathogenicity was evaluated in a specific-pathogen-free (SPF) chicken model. First, substitutions in different genes (N, P, F, SH, G, and L) and amino acid sites...
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