YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

Abstract excerpt

UNLABELLED: The Yes-associated protein (YAP)/Hippo pathway has been implicated in tissue development, regeneration, and tumorigenesis. However, its role in cholangiocarcinoma (CC) is not established. We show that YAP activation is a common feature in CC patient biopsies and human CC cell lines. Using microarray expression profiling of CC cells with overexpressed or down-regulated YAP, we show that YAP regulates...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hippo pathway signaling and YAP/TAZ
• Share to Liver physiology and pathology
• Share to Proteoglycans and glycosaminoglycans research