Article
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors.
Science signaling - 11 Sept 2018
Hagenbeek Thijs J, Webster Joshua D, Kljavin Noelyn M, Chang Matthew T, Pham Trang, Lee Ho-June, Klijn Christiaan, Cai Allen G, Totpal Klara, Ravishankar Buvana, Yang Naiying, Lee Da-Hye, Walsh Kevin B, Hatzivassiliou Georgia, de la Cruz Cecile C, Gould Stephen E, Wu Xiumin, Lee Wyne P, Yang Shuqun, Zhang Zhixiang, Gu Qingyang, Ji Qunsheng, Jackson Erica L, Lim Dae-Sik, Dey Anwesha
Abstract excerpt
The Hippo signaling pathway regulates organ size and plays critical roles in maintaining tissue growth, homeostasis, and regeneration. Dysregulated in a wide spectrum of cancers, in mammals, this pathway is regulated by two key effectors, YAP and TAZ, that may functionally overlap. We found that TAZ promoted liver inflammation and tumor development. The expression of TAZ, but not YAP, in human liver tumors...
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