Back to search

Article

Aberrant Hippo-YAP/TEAD signaling drives malignant transcriptional reprogramming in external auditory canal squamous cell carcinoma

2025-09-01

Abstract excerpt

<h4>Purpose</h4> External auditory canal squamous cell carcinoma (EACSCC) is an extremely rare malignancy. The molecular characteristics and evidence-based therapeutic strategies of EACSCC still remain to be elucidated. <h4>Experimental Design</h4> Comprehensive analyses of RNA sequencing (RNA-seq) and ChIP sequencing (ChIP-seq) utilizing YAP and H3K27Ac antibodies were performed in primary EACSCC and noncancero...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
48773a6d-e722-5466-b668-3063f7216118
DOI
10.1101/2025.08.27.672711
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Aberrant Hippo-YAP/TEAD signaling drives malignant transcriptional reprogramming in external auditory canal squamous cell carcinomaDOI 10.1101/2025.08.27.672711
TEAD transcription factor family emerges as a promising therapeutic target for oral squamous cell carcinomaSemantic proximity
Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote cancer immune evasionSemantic proximity
Molecular homology between canine spontaneous oral squamous cell carcinomas and human head-and-neck squamous cell carcinomas reveals disease drivers and therapeutic vulnerabilitiesSemantic proximity
Transcriptional reprogramming in oral squamous carcinomaSemantic proximity
The relationship between TEAD gene family and prognosis, tumor microenvironment and therapeutic target by pan-cancer analysisSemantic proximity
WITHDRAWN: The SOX4–PTBP2 Axis Promotes Proliferation, Invasion and Lymphatic Metastasis in Laryngeal Squamous Cell CarcinomaSemantic proximity
Updated Insights into the Molecular Pathophysiology of Olfactory Neuroblastoma Using Multi-Omics AnalysisSemantic proximity
Super-enhancer-driven ITGA6 enhances stemness features of squamous cell carcinoma through stabilizing c-myc proteinSemantic proximity
A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinomaSemantic proximity
Promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement and survivalSemantic proximity
ANO1 promotes malignant progression and epithelial–mesenchymal transition in head and neck squamous cell carcinoma through ERK/YAP-associated signalingSemantic proximity
A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinomaSemantic proximity
Select a neighboring publication to make it the new centre.