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Article

CLK1 Activates YAP to Promote Intrahepatic Cholangiocarcinogenesis

18 Dec 2024

Abstract excerpt

Cdc2-like kinase 1 (CLK1) has dual-specificity kinase ability to phosphorylate tyrosine and serine/threonine protein residues. CLK1 regulates many physiologic processes and has been shown to contribute to multiple types of cancer. In this study, we investigated the functional role of CLK1 during intrahepatic cholangiocarcinoma (ICC) development. The expression of CLK1 was elevated in ICC tumors, and patients with...

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PMID: 39693605
DOI: 10.1158/0008-5472.can-24-0147

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