Article
TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy.
Cell reports - 31 Oct 2017
Zhang Xiao, Sun Fenyong, Qiao Yongxia, Zheng Weisheng, Liu Ya, Chen Yan, Wu Qi, Liu Xiangfan, Zhu Guoqing, Chen Yuxin, Yu Yongchun, Pan Qiuhui, Wang Jiayi
Abstract excerpt
Although YAP-dependent transcription is closely associated with liver tumorigenesis, the mechanism by which YAP maintains its function is poorly understood. Here, we show that TFCP2 is required for YAP-dependent transcription and liver malignancy. Mechanistically, YAP function is stimulated by TFCP2 via a WW-PSY interaction. TFCP2 also maintains YAP stability by inhibiting βTrCP. Notably, genomic co-occupancy of...
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