Article
APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Apr 2016
Gutiérrez Orlando M, Judd Suzanne E, Irvin Marguerite R, Zhi Degui, Limdi Nita, Palmer Nicholette D, Rich Stephen S, Sale Michèle M, Freedman Barry I
Abstract excerpt
BACKGROUND: Two independent coding variants in the apolipoprotein L1 gene (APOL1), G1 and G2, strongly associate with nephropathy in African Americans; associations with cardiovascular disease are more controversial. Although APOL1 binds plasma high-density lipoproteins (HDLs), data on APOL1 risk variant associations with HDL subfractions are sparse. METHODS: Two APOL1 G1 single nucleotide polymorphisms and the...
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