Article
APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults.
Circulation. Genomic and precision medicine - 1 Jun 2018
Gutiérrez Orlando M, Irvin Marguerite R, Chaudhary Ninad S, Cushman Mary, Zakai Neil A, David Victor A, Limou Sophie, Pamir Nathalie, Reiner Alex P, Naik Rakhi P, Sale Michele M, Safford Monika M, Hyacinth Hyacinth I, Judd Suzanne E, Kopp Jeffrey B, Winkler Cheryl A
Abstract excerpt
BACKGROUND: APOL1 renal risk variants are strongly associated with chronic kidney disease in Black adults, but reported associations with cardiovascular disease (CVD) have been conflicting. METHODS: We examined associations of APOL1 with incident coronary heart disease (n=323), ischemic stroke (n=331), and the composite CVD outcome (n=500) in 10 605 Black participants of the REGARDS study (Reasons for Geographic...
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