Article
Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Nov 2011
Freedman Barry I, Langefeld Carl D, Murea Mariana, Ma Lijun, Otvos James D, Turner Jolyn, Antinozzi Peter A, Divers Jasmin, Hicks Pamela J, Bowden Donald W, Rocco Michael V, Parks John S
Abstract excerpt
BACKGROUND: Coding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with non-diabetic nephropathy in African Americans. ApoL1 proteins associate with high-density lipoprotein (HDL) particles in the circulation. Plasma HDL particle subclass concentrations were compared in 73 African Americans based on APOL1 genotypes to detect differences potentially contributing to renal disease. METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.