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Article

The evolving story of apolipoprotein L1 nephropathy: the end of the beginning.

Nature reviews. Nephrology - 1 May 2022

Daneshpajouhnejad Parnaz, Kopp Jeffrey B, Winkler Cheryl A, Rosenberg Avi Z

Abstract excerpt

Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were identified in 2010 and are relatively common among individuals of sub-Saharan African ancestry. Approximately 13% of African Americans carry two APOL1 risk alleles. These variants, termed G1 and G2, are a frequent cause of kidney disease - termed APOL1 nephropathy - that typically manifests as focal segmental glomerulosclerosis and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glomerulosclerosis, Focal Segmental

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Source

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Identifiers

PMID: 35217848
DOI: 10.1038/s41581-022-00538-3
PMCID: PMC8877744

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