Article
The Apolipoprotein L1 Gene and Cardiovascular Disease.
Methodist DeBakey cardiovascular journal - 1 Jan 2000
Robinson Todd W, Freedman Barry I
Abstract excerpt
Relative to those with European ancestry, African Americans have an excess incidence of nondiabetic chronic kidney disease predominantly due to two coding renal-risk variants in the apolipoprotein L1 gene (APOL1). This APOL1-kidney disease association is independent of systemic hypertension or blood pressure. Recent reports describe extra-renal effects of the APOL1 G1 and G2 renal-risk variants on cardiovascular...
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