Article
APOL1 variants associate with increased risk of CKD among African Americans.
Journal of the American Society of Nephrology : JASN - 1 Sept 2013
Foster Meredith C, Coresh Josef, Fornage Myriam, Astor Brad C, Grams Morgan, Franceschini Nora, Boerwinkle Eric, Parekh Rulan S, Kao W H Linda
Abstract excerpt
Although case-control studies suggest that African Americans with common coding variants in the APOL1 gene are 5-29 times more likely than those individuals without such variants to have focal segmental glomerulosclerosis, HIV-associated nephropathy, or ESRD, prospective studies have not yet evaluated the impact of these variants on CKD in a community-based sample of African Americans. Here, we studied whether...
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