Article
Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial.
Kidney international - 1 Jan 2015
Langefeld Carl D, Divers Jasmin, Pajewski Nicholas M, Hawfield Amret T, Reboussin David M, Bild Diane E, Kaysen George A, Kimmel Paul L, Raj Dominic S, Ricardo Ana C, Wright Jackson T, Sedor John R, Rocco Michael V, Freedman Barry I
Abstract excerpt
Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin:creatinine ratio (UACR), and prevalent cardiovascular disease (CVD) in 2571 AAs from the Systolic Blood Pressure Intervention Trial (SPRINT), a trial assessing...
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