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Article

Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2015

Grishkan Inna V, Tosi Dominique M, Bowman Melissa D, Harary Maya, Calabresi Peter A, Gocke Anne R

Abstract excerpt

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS that has been linked with defects in regulatory T cell function. Therefore, strategies to selectively target pathogenic cells via enhanced regulatory T cell activity may provide therapeutic benefit. Kv1.3 is a voltage-gated potassium channel expressed on myelin-reactive T cells from MS patients. Kv1.3-knockout (KO) mice are protected...

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Share to Encephalomyelitis, Autoimmune, Experimental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA1 Transcription Factor

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Share to Interleukin-2 Receptor alpha Subunit

Share to Myelin-Oligodendrocyte Glycoprotein

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Source

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Identifiers

PMID: 26150529
DOI: 10.4049/jimmunol.1403024
PMCID: PMC4530110

Genes

CTLA4
GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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