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Article

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.

Nature communications - 1 Mar 2017

Chiang Eugene Y, Li Tianbo, Jeet Surinder, Peng Ivan, Zhang Juan, Lee Wyne P, DeVoss Jason, Caplazi Patrick, Chen Jun, Warming Søren, Hackos David H, Mukund Susmith, Koth Christopher M, Grogan Jane L

Abstract excerpt

Voltage-gated Kv1.3 and Ca2+-dependent KCa3.1 are the most prevalent K+ channels expressed by human and rat T cells. Despite the preferential upregulation of Kv1.3 over KCa3.1 on autoantigen-experienced effector memory T cells, whether Kv1.3 is required for their induction and function is unclear. Here we show, using Kv1.3-deficient rats, that Kv1.3 is involved in the development of chronically activated...

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Identifiers

PMID: 28248292
DOI: 10.1038/ncomms14644
PMCID: PMC5337993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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