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Article

The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS.

The Journal of clinical investigation - 1 Jun 2003

Wulff Heike, Calabresi Peter A, Allie Rameeza, Yun Sung, Pennington Michael, Beeton Christine, Chandy K George

Abstract excerpt

Through a combination of fluorescence microscopy and patch-clamp analysis we have identified a striking alteration in K(+) channel expression in terminally differentiated human CCR7(-)CD45RA(-) effector memory T lymphocytes (T(EM)). Following activation, T(EM) cells expressed significantly higher levels of the voltage-gated K(+) channel Kv1.3 and lower levels of the calcium-activated K(+) channel IKCa1 than naive...

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Source

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Identifiers

PMID: 12782673
DOI: 10.1172/JCI16921
PMCID: PMC156104

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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