Article

Serpine1 negatively regulates Th1 cell responses in experimental autoimmune encephalomyelitis

2023-07-14

Abstract excerpt

Th1 cells are critical in experimental autoimmune encephalomyelitis (EAE). Serpine1 has been posited as an inhibitor of IFN γ from T cells though its role in autoimmunity remains unclear. Here, we show that Serpine1 knockout (KO) mice develop EAE of enhanced severity relative to wild-type (WT) controls. Serpine1 overexpression represses Th1 cell cytokine production and pathogenicity, while Serpine1-KO:2D2 Th1 cel...

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Literature Corpus work: ccd88730-aae3-5281-bd6a-1c59e6b99931
DOI: 10.1101/2023.07.13.548887

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