Article
Control of regulatory T cell development by the transcription factor Foxp3.
Science (New York, N.Y.) - 14 Feb 2003
Hori Shohei, Nomura Takashi, Sakaguchi Shimon
Abstract excerpt
Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+...
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