Article
Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2012
Gocke Anne R, Lebson Lori A, Grishkan Inna V, Hu Lina, Nguyen Hai M, Whartenby Katharine A, Chandy K George, Calabresi Peter A
Abstract excerpt
Increasing evidence suggests ion channels have critical functions in the differentiation and plasticity of T cells. Kv1.3, a voltage-gated K(+) channel, is a functional marker and a pharmacological target for activated effector memory T cells. Selective Kv1.3 blockers have been shown to inhibit proliferation and cytokine production by human and rat effector memory T cells. We used Kv1.3 knockout (KO) mice to...
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